Version 5.4
Mus musculus Gene: Zeb2
Summary
InnateDB Gene IDBG-168224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zeb2
Gene Name zinc finger E-box binding homeobox 2
Synonyms 9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b; Zfx1b; Zfxh1b
Species Mus musculus
Ensembl Gene ENSMUSG00000026872
Encoded Proteins
IDBP-168226
zinc finger E-box binding homeobox 2
IDBP-168228
zinc finger E-box binding homeobox 2
IDBP-168232
zinc finger E-box binding homeobox 2
IDBP-532093
zinc finger E-box binding homeobox 2
IDBP-719456
IDBP-718891
IDBP-718967
IDBP-718336
IDBP-719249
IDBP-718375
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169554:
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:44983634-45117395
Strand Reverse strand
Band B
Transcripts
ENSMUST00000076836 ENSMUSP00000076111
ENSMUST00000028229 ENSMUSP00000028229
ENSMUST00000068415 ENSMUSP00000069685
ENSMUST00000131635
ENSMUST00000145529
ENSMUST00000127520 ENSMUSP00000120130
ENSMUST00000153561 ENSMUSP00000135491
ENSMUST00000124942 ENSMUSP00000135790
ENSMUST00000152232 ENSMUSP00000135753
ENSMUST00000126743
ENSMUST00000123037
ENSMUST00000177302 ENSMUSP00000134747
ENSMUST00000176732 ENSMUSP00000135393
ENSMUST00000176438 ENSMUSP00000134849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0021766 hippocampus development
GO:0021846 cell proliferation in forebrain
GO:0030177 positive regulation of Wnt signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0045636 positive regulation of melanocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048023 positive regulation of melanin biosynthetic process
GO:0048066 developmental pigmentation
GO:0048598 embryonic morphogenesis
GO:0097324 melanocyte migration
GO:1903056 regulation of melanosome organization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169554
View Gene Order
ENSBTAG00000012615
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.402835 Mm.440702 Mm.443925 Mm.468060
RefSeq NM_001289521 NM_015753 XM_006498042 XM_006498043 XM_006498044 XM_006498045 XM_006498046 XM_006498047
OMIM
CCDS CCDS16020
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca