InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zeb2

Summary

InnateDB Protein

IDBP-168232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zeb2

Protein Name

zinc finger E-box binding homeobox 2

Synonyms

9130203F04Rik; D130016B08Rik; SIP1; Zfhx1b; Zfx1b; Zfxh1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069685

InnateDB Gene

IDBG-168224 (Zeb2)

Protein Structure

UniProt Annotation

Function

Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0021766	hippocampus development
GO:0021846	cell proliferation in forebrain
GO:0030177	positive regulation of Wnt signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0045636	positive regulation of melanocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048023	positive regulation of melanin biosynthetic process
GO:0048066	developmental pigmentation
GO:0048598	embryonic morphogenesis
GO:0097324	melanocyte migration
GO:1903056	regulation of melanosome organization