InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gjb6

Summary

InnateDB Protein

IDBP-168297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gjb6

Protein Name

gap junction protein, beta 6

Synonyms

AA958971; Cx30; D14Bwg0506e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035630

InnateDB Gene

IDBG-168295 (Gjb6)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Tissue Specificity

Highly expressed in adult brain and skin. Less in uterus, lung and eye. Very low in testis and sciatic nerve. No expression before birth.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007154	cell communication
GO:0007568	aging
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0042471	ear morphogenesis
GO:0048839	inner ear development
GO:0051602	response to electrical stimulus
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005829	cytosol
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle