InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grxcr1

Summary

InnateDB Protein

IDBP-168351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grxcr1

Protein Name

glutaredoxin, cysteine rich 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092305

InnateDB Gene

IDBG-168349 (Grxcr1)

Protein Structure

UniProt Annotation

Function

May play a role in actin filament architecture in developing stereocilia of sensory cells. {ECO:0000269PubMed:20137774}.

Subcellular Localization

Cell projection, stereocilium {ECO:0000269PubMed:20137774}. Cell projection, microvillus {ECO:0000269PubMed:20137774}. Cell projection, kinocilium {ECO:0000269PubMed:20137774}. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.

Disease Associations

Note=Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia. {ECO:0000269PubMed:11276175, ECO:0000269PubMed:20137774}.

Tissue Specificity

In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level). {ECO:0000269PubMed:20137774}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity

Biological Process

GO:0007605	sensory perception of sound
GO:0010923	negative regulation of phosphatase activity
GO:0042491	auditory receptor cell differentiation
GO:0045454	cell redox homeostasis
GO:0048563	post-embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0055114	oxidation-reduction process
GO:0060118	vestibular receptor cell development
GO:0060119	inner ear receptor cell development
GO:0060122	inner ear receptor stereocilium organization