InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tspo

Summary

InnateDB Protein

IDBP-168374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tspo

Protein Name

translocator protein

Synonyms

Bzrp; IBP; PBR; Tspo1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037039

InnateDB Gene

IDBG-168372 (Tspo)

Protein Structure

UniProt Annotation

Function

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060). {ECO:0000250, ECO:0000269PubMed:24174323, ECO:0000269PubMed:24814875, ECO:0000269PubMed:24936060, ECO:0000269PubMed:8114671, ECO:0000269PubMed:9832438}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). Ubiquitous. {ECO:0000269PubMed:24174323, ECO:0000269PubMed:24936060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005497	androgen binding
GO:0005515	protein binding
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007268	synaptic transmission
GO:0007568	aging
GO:0008347	glial cell migration
GO:0010042	response to manganese ion
GO:0010266	response to vitamin B1
GO:0010940	positive regulation of necrotic cell death
GO:0014012	peripheral nervous system axon regeneration
GO:0030325	adrenal gland development
GO:0032570	response to progesterone
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033574	response to testosterone
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048678	response to axon injury
GO:0050810	regulation of steroid biosynthetic process
GO:0051901	positive regulation of mitochondrial depolarization
GO:0051928	positive regulation of calcium ion transport
GO:0060242	contact inhibition
GO:0060252	positive regulation of glial cell proliferation
GO:0060253	negative regulation of glial cell proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:0071294	cellular response to zinc ion
GO:0071476	cellular hypotonic response
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome