Version 5.4
Mus musculus Gene: Tspo
Summary
InnateDB Gene IDBG-168372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tspo
Gene Name translocator protein
Synonyms Bzrp; IBP; PBR; Tspo1
Species Mus musculus
Ensembl Gene ENSMUSG00000041736
Encoded Proteins
IDBP-168374
translocator protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100300:
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:83563573-83574201
Strand Forward strand
Band E1
Transcripts
ENSMUST00000047419 ENSMUSP00000037039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005497 androgen binding
GO:0005515 protein binding
GO:0008503 benzodiazepine receptor activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007268 synaptic transmission
GO:0007568 aging
GO:0008347 glial cell migration
GO:0010042 response to manganese ion
GO:0010266 response to vitamin B1
GO:0010940 positive regulation of necrotic cell death
GO:0014012 peripheral nervous system axon regeneration
GO:0030325 adrenal gland development
GO:0032570 response to progesterone
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033574 response to testosterone
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0048678 response to axon injury
GO:0050810 regulation of steroid biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0060242 contact inhibition
GO:0060252 positive regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:0071294 cellular response to zinc ion
GO:0071476 cellular hypotonic response
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100300
View Gene Order
ENSBTAG00000018073
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P50637
TrEMBL Q541E3
UniProt Splice Variant
Entrez Gene 12257
UniGene
RefSeq NM_009775 XM_006520358
OMIM
CCDS CCDS27705
HPRD
IMGT
MGI ID MGI:88222
MGI Symbol Tspo
EMBL AK149743 AK150516 AK151421 AK151569 AK151824 AK152082 AK152827 AK153159 AK153273 AK156489 AK165450 AK165822 AK166125 AK172384 AY079441 AY079442 CH466550 D21207 L17306 U12419
GenPept AAA20127 AAA83253 AAL87529 AAL87530 BAA04749 BAE29056 BAE29628 BAE30386 BAE30511 BAE30721 BAE30932 BAE31528 BAE31769 BAE31860 BAE33730 BAE38192 BAE38396 BAE38585 BAE42976 EDL04468
RNA Seq Atlas 12257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca