InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnmt3l

Summary

InnateDB Protein

IDBP-168383.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt3l

Protein Name

DNA (cytosine-5-)-methyltransferase 3-like

Synonyms

D6Ertd14e; ecat7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000746

InnateDB Gene

IDBG-168381 (Dnmt3l)

Protein Structure

UniProt Annotation

Function

Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. {ECO:0000269PubMed:11719692, ECO:0000269PubMed:15671018}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in testis, thymus, ovary, and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0032259	methylation
GO:0043085	positive regulation of catalytic activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060718	chorionic trophoblast cell differentiation
GO:0071514	genetic imprinting