InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ltc4s

Summary

InnateDB Protein

IDBP-168453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltc4s

Protein Name

leukotriene C4 synthase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099833

InnateDB Gene

IDBG-168449 (Ltc4s)

Protein Structure

UniProt Annotation

Function

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Subcellular Localization

Nucleus outer membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8706658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008289	lipid binding

Biological Process

GO:0006691	leukotriene metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0043085	positive regulation of catalytic activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005635	nuclear envelope
GO:0005640	nuclear outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane