InnateDB Protein
|
IDBP-16848.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CLEC4A
|
Protein Name
|
C-type lectin domain family 4, member A
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000247243
|
InnateDB Gene
|
IDBG-16844 (CLEC4A)
|
Protein Structure
|
|
Function |
May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269PubMed:10438934}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269PubMed:10438934, ECO:0000269PubMed:11178971, ECO:0000269PubMed:11994513}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0004888
|
transmembrane signaling receptor activity
|
GO:0030246
|
carbohydrate binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
|
PFAM |
PF00059
|
PRINTS |
PR00356
|
PIRSF |
|
SMART |
SM00034
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UMR7
|
PhosphoSite |
PhosphoSite-Q9UMR7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
50856
|
UniGene |
Hs.504657
|
RefSeq |
NP_919432
|
HUGO |
HGNC:13257
|
OMIM |
605306
|
CCDS |
CCDS8592
|
HPRD |
05604
|
IMGT |
|
EMBL |
AC006511
AC092111
AF067800
AF109146
AF200738
AF328684
AJ133532
BC074822
BC074874
BC117439
BC117441
|
GenPept |
AAF14348
AAF75560
AAG35593
AAH74822
AAH74874
AAI17440
AAI17442
AAL56016
CAB54001
|
|
|