Version 5.4
Homo sapiens Protein: CLEC4A
Summary
InnateDB Protein IDBP-16850.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4A
Protein Name C-type lectin domain family 4, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353690
InnateDB Gene IDBG-16844 (CLEC4A)
Protein Structure
UniProt Annotation
Function May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269PubMed:10438934}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). {ECO:0000269PubMed:10438934, ECO:0000269PubMed:11178971, ECO:0000269PubMed:11994513}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UMR7
PhosphoSite PhosphoSite-Q9UMR7
TrEMBL
UniProt Splice Variant
Entrez Gene 50856
UniGene Hs.504657
RefSeq NP_919429
HUGO HGNC:13257
OMIM 605306
CCDS CCDS41745
HPRD 05604
IMGT
EMBL AC006511 AC092111 AF067800 AF109146 AF200738 AF328684 AJ133532 BC074822 BC074874 BC117439 BC117441
GenPept AAF14348 AAF75560 AAG35593 AAH74822 AAH74874 AAI17440 AAI17442 AAL56016 CAB54001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca