Version 5.4
Mus musculus Protein: Vps52
Summary
InnateDB Protein IDBP-168607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps52
Protein Name vacuolar protein sorting 52 (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025178
InnateDB Gene IDBG-168605 (Vps52)
Protein Structure
UniProt Annotation
Function May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010668 ectodermal cell differentiation
GO:0015031 protein transport
GO:0048611 embryonic ectodermal digestive tract development
Cellular Component
GO:0005575 cellular_component
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
Protein Structure and Domains
PDB ID MGI:1330304
InterPro IPR007258 Vps52/Sac2
IPR019160 Exocyst complex, component 1/SEC3
PFAM PF04129
PF09763
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C754
PhosphoSite PhosphoSite-Q8C754
TrEMBL
UniProt Splice Variant
Entrez Gene 224705
UniGene Mm.485758
RefSeq NP_766208
MGI ID
MGI Symbol Vps52
OMIM
CCDS CCDS37574
HPRD
IMGT
EMBL AF100956 AF110520 AK051732 AK052523 BC063329
GenPept AAC69899 AAC97979 AAH63329 BAC34741 BAC35024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca