Mus musculus Protein: F2rl3
Summary
InnateDB Protein IDBP-168610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2rl3
Protein Name coagulation factor II (thrombin) receptor-like 3
Synonyms PAR4;
Species Mus musculus
Ensembl Protein ENSMUSP00000054426
InnateDB Gene IDBG-168608 (F2rl3)
Protein Structure
UniProt Annotation
Function Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highly expressed in the spleen. Slight expression in the heart, lung, skeletal muscle and kidney. No detectable expression in brain, liver or testis. Also detected in platelets.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0015057 thrombin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0070493 thrombin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1298207
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003912 Protease-activated receptor
IPR003944 Protease-activated receptor 4
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR01428
PR01430
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88634
PhosphoSite PhosphoSite-O88634
TrEMBL Q0VDX1
UniProt Splice Variant
Entrez Gene 14065
UniGene Mm.12948
RefSeq NP_032001
MGI ID 2PV9
MGI Symbol F2rl3
OMIM
CCDS CCDS22419
HPRD
IMGT
EMBL AF080215 AK036427 AK153720 AK156729 BC119461 CH466525
GenPept AAC28861 AAI19462 BAC29423 BAE32155 BAE33823 EDL10818