Version 5.4
| Mus musculus Gene: F2rl3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-168608.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | F2rl3 | ||||||||||||||||||
| Gene Name | coagulation factor II (thrombin) receptor-like 3 | ||||||||||||||||||
| Synonyms | PAR4 | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000050147 | ||||||||||||||||||
| Encoded Proteins |
coagulation factor II (thrombin) receptor-like 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Homo sapiens] F2RL3 modulates inflammation in the lung where its activation stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127533:
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:72761880-72763874 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | B3.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Platelet activation, signaling and aggregation pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||||||||||||
| PID NCI |
PAR4-mediated thrombin signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | O88634 | ||||||||||||||||||
| TrEMBL | Q0VDX1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 14065 | ||||||||||||||||||
| UniGene | Mm.12948 | ||||||||||||||||||
| RefSeq | NM_007975 XM_006530660 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS22419 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1298207 | ||||||||||||||||||
| MGI Symbol | F2rl3 | ||||||||||||||||||
| EMBL | AF080215 AK036427 AK153720 AK156729 BC119461 CH466525 | ||||||||||||||||||
| GenPept | AAC28861 AAI19462 BAC29423 BAE32155 BAE33823 EDL10818 | ||||||||||||||||||
| RNA Seq Atlas | 14065 | ||||||||||||||||||