InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tyrobp

Summary

InnateDB Protein

IDBP-168771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyrobp

Protein Name

TYRO protein tyrosine kinase binding protein

Synonyms

DAP12; KARAP; Ly83;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032800

InnateDB Gene

IDBG-168769 (Tyrobp)

Protein Structure

UniProt Annotation

Function

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. {ECO:0000269PubMed:17086186}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002283	neutrophil activation involved in immune response
GO:0007229	integrin-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:2001204	regulation of osteoclast development