InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tyrobp

Summary

InnateDB Gene

IDBG-168769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyrobp

Gene Name

TYRO protein tyrosine kinase binding protein

Synonyms

DAP12; KARAP; Ly83

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030579

Encoded Proteins

IDBP-168771

TYRO protein tyrosine kinase binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25402298

Tyrobp impairs host defence during pneumococcal pneumonia at the primary site of infection by inhibiting phagocytosis by alveolar macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011600:
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:30413788-30417577

Strand

Forward strand

Band

Transcripts

ENSMUST00000032800

ENSMUSP00000032800

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002283	neutrophil activation involved in immune response
GO:0007229	integrin-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:2001204	regulation of osteoclast development