InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mier1

Summary

InnateDB Protein

IDBP-168804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mier1

Protein Name

mesoderm induction early response 1 homolog (Xenopus laevis

Synonyms

4933425I22Rik; 5830411K19Rik; er1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095558

InnateDB Gene

IDBG-168800 (Mier1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269PubMed:16147882}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Isoform 1 is only expressed in testis. {ECO:0000269PubMed:16147882}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004871	signal transducer activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0031937	positive regulation of chromatin silencing
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling