Version 5.4
Mus musculus Gene: Mier1
Summary
InnateDB Gene IDBG-168800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mier1
Gene Name mesoderm induction early response 1 homolog (Xenopus laevis
Synonyms 4933425I22Rik; 5830411K19Rik; er1
Species Mus musculus
Ensembl Gene ENSMUSG00000028522
Encoded Proteins
IDBP-168802
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-168804
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-267880
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-267882
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-267886
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-531956
mesoderm induction early response 1 homolog (Xenopus laevis
IDBP-534694
mesoderm induction early response 1 homolog (Xenopus laevis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198160:
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms; some of which contain a nuclear localization signal. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:103114390-103165754
Strand Forward strand
Band C6
Transcripts
ENSMUST00000030247 ENSMUSP00000030247
ENSMUST00000097945 ENSMUSP00000095558
ENSMUST00000106858 ENSMUSP00000102471
ENSMUST00000106857 ENSMUSP00000102470
ENSMUST00000106855 ENSMUSP00000102468
ENSMUST00000136092
ENSMUST00000137348
ENSMUST00000149259
ENSMUST00000143417 ENSMUSP00000121587
ENSMUST00000144219
ENSMUST00000134533 ENSMUSP00000123637
ENSMUST00000147491
ENSMUST00000151588
ENSMUST00000124348
ENSMUST00000128536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0031937 positive regulation of chromatin silencing
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198160
View Gene Order
ENSBTAG00000005443
Not yet available
Cross-References
SwissProt Q5UAK0
TrEMBL B1AY31 Q8C929
UniProt Splice Variant
Entrez Gene 71148
UniGene Mm.288721 Mm.406516 Mm.409743 Mm.411890 Mm.442381 Mm.466022
RefSeq XM_006503401 NM_001039081 NM_001286221 NM_001286222 NM_001286223 NM_027696 XM_006503398 XM_006503399 XM_006503400 XM_006503402 XM_006503403 XM_006503404
OMIM
CCDS CCDS18408 CCDS38825 CCDS71432
HPRD
IMGT
MGI ID MGI:1918398
MGI Symbol Mier1
EMBL AK016915 AK043136 AK129405 AK136467 AL844176 AY769435 AY769436 AY769437 AY769438 BC130227
GenPept AAI30228 AAV37181 AAV37182 AAV37183 AAV37184 BAB30493 BAC31472 BAC98215 BAE22989 CAM27551 CAM27556
RNA Seq Atlas 71148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca