InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc5a7

Summary

InnateDB Protein

IDBP-168866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc5a7

Protein Name

solute carrier family 5 (choline transporter), member 7

Synonyms

CHT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093379

InnateDB Gene

IDBG-191020 (Slc5a7)

Protein Structure

UniProt Annotation

Function

Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. {ECO:0000269PubMed:15173594}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in spinal cord, brain-stem, mid-brain and striatum. Specific for cholinergic neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005307	choline:sodium symporter activity
GO:0005515	protein binding
GO:0015220	choline transmembrane transporter activity
GO:0033265	choline binding

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007271	synaptic transmission, cholinergic
GO:0007274	neuromuscular synaptic transmission
GO:0008292	acetylcholine biosynthetic process
GO:0015871	choline transport
GO:0055085	transmembrane transport