InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc5a7

Summary

InnateDB Gene

IDBG-191020.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc5a7

Gene Name

solute carrier family 5 (choline transporter), member 7

Synonyms

CHT1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023945

Encoded Proteins

IDBP-168866

solute carrier family 5 (choline transporter), member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115665:
Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:54273594-54299034

Strand

Reverse strand

Band

Transcripts

ENSMUST00000095712

ENSMUSP00000093379

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005307	choline:sodium symporter activity
GO:0005515	protein binding
GO:0015220	choline transmembrane transporter activity
GO:0033265	choline binding

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007271	synaptic transmission, cholinergic
GO:0007274	neuromuscular synaptic transmission
GO:0008292	acetylcholine biosynthetic process
GO:0015871	choline transport
GO:0055085	transmembrane transport