InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gabra2

Summary

InnateDB Protein

IDBP-168962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabra2

Protein Name

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2

Synonyms

C630048P16Rik; Gabra-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000572

InnateDB Gene

IDBG-168960 (Gabra2)

Protein Structure

UniProt Annotation

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0006810	transport
GO:0006811	ion transport
GO:0006836	neurotransmitter transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030285	integral component of synaptic vesicle membrane
GO:0030424	axon
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95614

InterPro

IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR01079
PR01615
PR01620
PR00253
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26048