InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabra2

Summary

InnateDB Gene

IDBG-168960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabra2

Gene Name

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2

Synonyms

C630048P16Rik; Gabra-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000560

Encoded Proteins

IDBP-168962

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151834:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:70961057-71095849

Strand

Reverse strand

Band

C3.1

Transcripts

ENSMUST00000000572

ENSMUSP00000000572

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0006810	transport
GO:0006811	ion transport
GO:0006836	neurotransmitter transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030285	integral component of synaptic vesicle membrane
GO:0030424	axon
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane