InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CORIN

Summary

InnateDB Protein

IDBP-16907.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORIN

Protein Name

corin, serine peptidase

Synonyms

ATC2; CRN; Lrp4; PEE5; TMPRSS10;

Species

Homo sapiens

Ensembl Protein

ENSP00000273857

InnateDB Gene

IDBG-16903 (CORIN)

Protein Structure

UniProt Annotation

Function

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19751717, ECO:0000269PubMed:21288900, ECO:0000269PubMed:21518754}; Single- pass type II membrane protein {ECO:0000269PubMed:19751717, ECO:0000269PubMed:21288900, ECO:0000269PubMed:21518754}. Note=May easily detached from the endothelial cell membrane.Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10.Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.

Disease Associations

Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269PubMed:22437503}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). {ECO:0000269PubMed:10329693, ECO:0000269PubMed:19751717, ECO:0000269PubMed:22437503}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0006508	proteolysis
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0016486	peptide hormone processing
GO:0035813	regulation of renal sodium excretion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017052 Peptidase S1A, corin
IPR017448 SRCR-like domain
IPR020067 Frizzled domain

PFAM

PF00089
PF00057
PF01392

PRINTS

PR00722
PR00261

PIRSF

PIRSF036376

SMART

SM00020
SM00192
SM00202
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References