Version 5.4
Homo sapiens Gene: CORIN
Summary
InnateDB Gene IDBG-16903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CORIN
Gene Name corin, serine peptidase
Synonyms ATC2; CRN; Lrp4; PEE5; TMPRSS10
Species Homo sapiens
Ensembl Gene ENSG00000145244
Encoded Proteins
IDBP-16907
corin, serine peptidase
IDBP-485332
corin, serine peptidase
IDBP-476983
corin, serine peptidase
IDBP-480176
corin, serine peptidase
IDBP-482936
corin, serine peptidase
IDBP-812941
corin, serine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. [provided by RefSeq, Jul 2008]
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:47593998-47838106
Strand Reverse strand
Band p12
Transcripts
ENST00000273857 ENSP00000273857
ENST00000508498 ENSP00000425597
ENST00000502252 ENSP00000424212
ENST00000505909 ENSP00000425401
ENST00000515827
ENST00000505754
ENST00000504584 ENSP00000423216
ENST00000503821
ENST00000502726
ENST00000510974
ENST00000610355 ENSP00000484087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0006508 proteolysis
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0016486 peptide hormone processing
GO:0035813 regulation of renal sodium excretion
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005220
View Gene Order
ENSBTAG00000002199
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8IZR7
UniProt Splice Variant
Entrez Gene 10699
UniGene
RefSeq NM_001278585 NM_001278586 NM_006587
HUGO HGNC:19012
OMIM 605236
CCDS CCDS75122 CCDS3477 CCDS63958
HPRD
IMGT
EMBL AF521006
GenPept AAN40016
RNA Seq Atlas 10699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca