InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpox

Summary

InnateDB Protein

IDBP-169111.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpox

Protein Name

coproporphyrinogen oxidase

Synonyms

cac; Cpo; CPX; HCP; nct;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055455

InnateDB Gene

IDBG-169109 (Cpox)

Protein Structure

UniProt Annotation

Function

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion intermembrane space.

Disease Associations

Tissue Specificity

Erythroid cells and non erythroid cells such as liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004109	coproporphyrinogen oxidase activity
GO:0005212	structural constituent of eye lens
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0010035	response to inorganic substance
GO:0010039	response to iron ion
GO:0010288	response to lead ion
GO:0017085	response to insecticide
GO:0035725	sodium ion transmembrane transport
GO:0046685	response to arsenic-containing substance
GO:0051597	response to methylmercury
GO:0055114	oxidation-reduction process