InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cpox

Summary

InnateDB Gene

IDBG-169109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpox

Gene Name

coproporphyrinogen oxidase

Synonyms

cac; Cpo; CPX; HCP; nct

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022742

Encoded Proteins

IDBP-169111

coproporphyrinogen oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080819:
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:58670208-58680391

Strand

Forward strand

Band

C1.2

Transcripts

ENSMUST00000060077

ENSMUSP00000055455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004109	coproporphyrinogen oxidase activity
GO:0005212	structural constituent of eye lens
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0010035	response to inorganic substance
GO:0010039	response to iron ion
GO:0010288	response to lead ion
GO:0017085	response to insecticide
GO:0035725	sodium ion transmembrane transport
GO:0046685	response to arsenic-containing substance
GO:0051597	response to methylmercury
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000080819

View Gene Order

ENSBTAG00000004124

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_203298

Heme biosynthesis pathway

REACT_233360

Metabolism of porphyrins pathway

KEGG

mmu00860

Porphyrin and chlorophyll metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_9465

Heme biosynthesis pathway

REACT_9431

Metabolism of porphyrins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00860

Porphyrin and chlorophyll metabolism pathway

INOH

INOH website

Porphyrin metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.291519 Mm.405044

RefSeq

NM_007757

OMIM

CCDS

CCDS49878

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas