InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bdkrb1

Summary

InnateDB Protein

IDBP-169237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdkrb1

Protein Name

bradykinin receptor, beta 1

Synonyms

B1BKR; B1R; Bdkrb; BKR1; BRADYB1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045335

InnateDB Gene

IDBG-169235 (Bdkrb1)

Protein Structure

UniProt Annotation

Function

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in heart, liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004947	bradykinin receptor activity
GO:0005515	protein binding
GO:0042277	peptide binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009612	response to mechanical stimulus
GO:0016477	cell migration
GO:0019233	sensory perception of pain
GO:0030308	negative regulation of cell growth
GO:0032496	response to lipopolysaccharide
GO:0045776	negative regulation of blood pressure
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:88144

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000496 Bradykinin receptor family
IPR001186 Bradykinin receptor B1
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00425
PR00993

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61125