InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bdkrb1

Summary

InnateDB Gene

IDBG-169235.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bdkrb1

Gene Name

bradykinin receptor, beta 1

Synonyms

B1BKR; B1R; Bdkrb; BKR1; BRADYB1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041347

Encoded Proteins

IDBP-169237

bradykinin receptor, beta 1

IDBP-788477

bradykinin receptor, beta 1

IDBP-788479

bradykinin receptor, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100739:
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:105603085-105605428

Strand

Forward strand

Band

Transcripts

ENSMUST00000041229	ENSMUSP00000045335
ENSMUST00000182899	ENSMUSP00000138118
ENSMUST00000183086	ENSMUSP00000138216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004947	bradykinin receptor activity
GO:0005515	protein binding
GO:0042277	peptide binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009612	response to mechanical stimulus
GO:0016477	cell migration
GO:0019233	sensory perception of pain
GO:0030308	negative regulation of cell growth
GO:0032496	response to lipopolysaccharide
GO:0045776	negative regulation of blood pressure
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol