InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2-Ke6

Summary

InnateDB Protein

IDBP-169365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-Ke6

Protein Name

H2-K region expressed gene 6

Synonyms

D17H6S112E; H-2Ke6; Hsd17b8; Ke-6; Ke6; Ring2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038069

InnateDB Gene

IDBG-169363 (H2-Ke6)

Protein Structure

UniProt Annotation

Function

NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (By similarity). The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Kidney, liver, testis, ovary, oviduct, uterus, mammary gland, vagina, prostate, clitoral gland and moderately in spleen, heart, dorsal skin, brain and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95911

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References