InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: H2-Ke6

Summary

InnateDB Gene

IDBG-169363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-Ke6

Gene Name

H2-K region expressed gene 6

Synonyms

D17H6S112E; H-2Ke6; Hsd17b8; Ke-6; Ke6; Ring2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000073422

Encoded Proteins

IDBP-169365

H2-K region expressed gene 6

IDBP-626881

H2-K region expressed gene 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204228:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34026033-34028060

Strand

Reverse strand

Band

Transcripts

ENSMUST00000045467	ENSMUSP00000038069
ENSMUST00000114303	ENSMUSP00000133546
ENSMUST00000173616
ENSMUST00000173425
ENSMUST00000170644
ENSMUST00000174029
ENSMUST00000174399
ENSMUST00000173894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204228

View Gene Order

ENSBTAG00000020927

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00140

Steroid hormone biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00140

Steroid hormone biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_013543

OMIM

CCDS

CCDS50071

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas