InnateDB Protein
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IDBP-169385.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rif1
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Protein Name
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Rap1 interacting factor 1 homolog (yeast)
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Synonyms
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5730435J01Rik; 6530403D07Rik; AU016181; AW549474; D2Ertd145e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000064155
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InnateDB Gene
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IDBG-169383 (Rif1)
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Protein Structure
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Function |
Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15042697}. Chromosome, telomere {ECO:0000269PubMed:15042697}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (By similarity). While the majority of the protein appears nuclear and distinct from normal telomere structures, a small fraction may bind to telomeres in embryonic stem cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation. {ECO:0000269PubMed:15042697}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
105 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1098622
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InterPro |
IPR016024
Armadillo-type fold
IPR022031
Telomere-associated protein Rif1, N-terminal
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PFAM |
PF12231
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PR54
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PhosphoSite |
PhosphoSite-Q6PR54
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TrEMBL |
Q8CEM8
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UniProt Splice Variant |
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Entrez Gene |
51869
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UniGene |
Mm.473801
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RefSeq |
XP_006498237
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MGI ID |
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MGI Symbol |
Rif1
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OMIM |
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CCDS |
CCDS50583
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HPRD |
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IMGT |
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EMBL |
AK017618
AK018316
AK083291
AK088688
AY428571
AY585206
BC055320
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GenPept |
AAH55320
AAR87833
AAS94124
BAB30843
BAC25553
BAC38846
BAC40506
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