InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Corin

Summary

InnateDB Protein

IDBP-169669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Corin

Protein Name

corin

Synonyms

AV273130; Lrp4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005352

InnateDB Gene

IDBG-169667 (Corin)

Protein Structure

UniProt Annotation

Function

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. {ECO:0000269PubMed:11884416, ECO:0000269PubMed:15637153, ECO:0000269PubMed:20613715, ECO:0000269PubMed:22418978, ECO:0000269PubMed:22437503}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted {ECO:0000250}. Note=Soluble form produced following cleavage by ADAM10. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart. Also expressed in pregnant uterus. {ECO:0000269PubMed:22437503}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0016486	peptide hormone processing
GO:0030182	neuron differentiation
GO:0035813	regulation of renal sodium excretion

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1349451

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017052 Peptidase S1A, corin
IPR017448 SRCR-like domain
IPR020067 Frizzled domain

PFAM

PF00530
PF00089
PF00057
PF01392

PRINTS

PR00258
PR00722
PR00261

PIRSF

PIRSF036376

SMART

SM00020
SM00192
SM00202
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References