InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Corin

Summary

InnateDB Gene

IDBG-169667.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Corin

Gene Name

corin

Synonyms

AV273130; Lrp4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005220

Encoded Proteins

IDBP-169669

corin

IDBP-628349

corin

IDBP-725197

IDBP-724917

IDBP-725181

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145244:
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. [provided by RefSeq, Jul 2008]
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:72300025-72504473

Strand

Reverse strand

Band

C3.2

Transcripts

ENSMUST00000005352	ENSMUSP00000005352
ENSMUST00000167460	ENSMUSP00000127389
ENSMUST00000177290	ENSMUSP00000135511
ENSMUST00000176974	ENSMUSP00000135722
ENSMUST00000176320
ENSMUST00000175766	ENSMUSP00000135889
ENSMUST00000176439

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0070008	serine-type exopeptidase activity

Biological Process

GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide
GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0016486	peptide hormone processing
GO:0030182	neuron differentiation
GO:0035813	regulation of renal sodium excretion

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145244

View Gene Order

ENSBTAG00000002199

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9Z319

TrEMBL

H3BKS9 H3BLB2 H3BLR7

UniProt Splice Variant

Entrez Gene

53419

UniGene

Mm.332425

RefSeq

NM_001122756 NM_016869

OMIM

CCDS

CCDS19330 CCDS51513

HPRD

IMGT

MGI ID

MGI:1349451

MGI Symbol

Corin

EMBL

AB013874 AC129608 AC161529 BC093485 BC138339 BC138340 CH466524

GenPept

AAH93485 AAI38340 AAI38341 BAA34371 EDL37819

RNA Seq Atlas

53419