Version 5.4
| Mus musculus Protein: C8a | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-169704.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | C8a | ||||||||
| Protein Name | complement component 8, alpha polypeptide | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000067541 | ||||||||
| InnateDB Gene | IDBG-169700 (C8a) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells (By similarity). {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2668347 | ||||||||
| InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR001862 Membrane attack complex component/perforin/complement C9 IPR002172 Low-density lipoprotein (LDL) receptor class A repeat IPR020864 Membrane attack complex component/perforin (MACPF) domain |
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| PFAM |
PF00090
PF00057 PF01823 |
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| PRINTS |
PR00764
PR00261 |
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| PIRSF | |||||||||
| SMART |
SM00209
SM00192 SM00457 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8K182 | ||||||||
| PhosphoSite | PhosphoSite-Q8K182 | ||||||||
| TrEMBL | Q8K1T2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 230558 | ||||||||
| UniGene | Mm.197638 | ||||||||
| RefSeq | NP_666260 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | C8a | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18415 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB077295 AB077296 AB077298 AB077299 AB077301 AJ409152 BC027748 | ||||||||
| GenPept | AAH27748 BAC41360 BAC41361 BAC41363 BAC41364 BAC41366 CAC85159 | ||||||||