Version 5.4
Mus musculus Gene: C8a
Summary
InnateDB Gene IDBG-169700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C8a
Gene Name complement component 8, alpha polypeptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035031
Encoded Proteins
IDBP-169702
complement component 8, alpha polypeptide
IDBP-169704
complement component 8, alpha polypeptide
IDBP-267980
complement component 8, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12220191
[Homo sapiens] C8A is the alpha subunit of complement factor 8 (C8) and is one of five components that interact to form the cytolytic membrane attack complex (MAC).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157131:
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:104815679-104876398
Strand Reverse strand
Band C6
Transcripts
ENSMUST00000048947 ENSMUSP00000047606
ENSMUST00000064873 ENSMUSP00000067541
ENSMUST00000106808 ENSMUSP00000102420
ENSMUST00000152146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001848 complement binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157131
View Gene Order
ENSBTAG00000003774
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_230745
Immune System pathway
REACT_215211
Terminal pathway of complement pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2A997 Q8BH67 Q8K1T2
UniProt Splice Variant
Entrez Gene 230558
UniGene Mm.197638
RefSeq XM_006502943 NM_001290645 NM_146148 XM_006502940 XM_006502941 XM_006502942
OMIM
CCDS CCDS18415 CCDS71433
HPRD
IMGT
MGI ID MGI:2668347
MGI Symbol C8a
EMBL AB077299 AB077301 AJ409152 AL627186
GenPept BAC41364 BAC41366 CAC85159
RNA Seq Atlas 230558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca