InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Papola

Summary

InnateDB Protein

IDBP-169754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Papola

Protein Name

poly (A) polymerase alpha

Synonyms

Pap; PapIII; Plap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021535

InnateDB Gene

IDBG-169752 (Papola)

Protein Structure

UniProt Annotation

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, thymus, lung, kidney, bladder, testis and spleen. {ECO:0000269PubMed:18281463}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003723	RNA binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005524	ATP binding
GO:0016779	nucleotidyltransferase activity
GO:0030145	manganese ion binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0031123	RNA 3'-end processing
GO:0043631	RNA polyadenylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109301

InterPro

IPR002934 Nucleotidyl transferase domain
IPR007010 Poly(A) polymerase, RNA-binding domain
IPR007012 Poly(A) polymerase, central domain
IPR011068 Nucleotidyltransferase, class I, C-terminal-like
IPR014492 Poly(A) polymerase

PFAM

PF01909
PF04926
PF04928

PRINTS

PIRSF

PIRSF018425

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61183