Version 5.4
Mus musculus Gene: Papola
Summary
InnateDB Gene IDBG-169752.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Papola
Gene Name poly (A) polymerase alpha
Synonyms Pap; PapIII; Plap
Species Mus musculus
Ensembl Gene ENSMUSG00000021111
Encoded Proteins
IDBP-169754
poly (A) polymerase alpha
IDBP-261405
poly (A) polymerase alpha
IDBP-622649
poly (A) polymerase alpha
IDBP-622653
poly (A) polymerase alpha
IDBP-622658
poly (A) polymerase alpha
IDBP-622659
poly (A) polymerase alpha
IDBP-622661
poly (A) polymerase alpha
IDBP-622662
poly (A) polymerase alpha
IDBP-622664
poly (A) polymerase alpha
IDBP-622666
poly (A) polymerase alpha
IDBP-622669
poly (A) polymerase alpha
IDBP-622671
poly (A) polymerase alpha
IDBP-622674
poly (A) polymerase alpha
IDBP-622676
poly (A) polymerase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090060:
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3\'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:105784694-105838944
Strand Forward strand
Band E
Transcripts
ENSMUST00000021535 ENSMUSP00000021535
ENSMUST00000109901 ENSMUSP00000105527
ENSMUST00000168186 ENSMUSP00000128402
ENSMUST00000172040
ENSMUST00000163473 ENSMUSP00000131668
ENSMUST00000166498
ENSMUST00000166329 ENSMUSP00000131725
ENSMUST00000165584
ENSMUST00000169938 ENSMUSP00000130687
ENSMUST00000164326 ENSMUSP00000125818
ENSMUST00000170540 ENSMUSP00000130714
ENSMUST00000166735 ENSMUSP00000128908
ENSMUST00000170002 ENSMUSP00000126275
ENSMUST00000163805
ENSMUST00000169524 ENSMUSP00000130798
ENSMUST00000170831
ENSMUST00000166471 ENSMUSP00000132353
ENSMUST00000164798 ENSMUSP00000125898
ENSMUST00000170189
ENSMUST00000172089 ENSMUSP00000131729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0030145 manganese ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006369 termination of RNA polymerase II transcription
GO:0006378 mRNA polyadenylation
GO:0031123 RNA 3'-end processing
GO:0043631 RNA polyadenylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000090060
View Gene Order
ENSBTAG00000004054
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_249110
mRNA Splicing pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_232123
Processing of Intronless Pre-mRNAs pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_204974
Processing of Capped Intronless Pre-mRNA pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_225642
Processing of Intronless Pre-mRNAs pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.255877 Mm.401689 Mm.413510 Mm.486949
RefSeq NM_011112 XM_006515592 XM_006515593 XM_006515596 XM_006515597
OMIM
CCDS CCDS49163
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca