InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgap33

Summary

InnateDB Protein

IDBP-169822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap33

Protein Name

Rho GTPase activating protein 33

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038412

InnateDB Gene

IDBG-169820 (Arhgap33)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin- stimulated glucose transport. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12773384}. Note=Translocates to the plasma membrane in response to insulin in adipocytes.

Disease Associations

Tissue Specificity

Highly expressed in brain and testis. Also expressed in white adipose tissue (WAT) and muscle at a low level. {ECO:0000269PubMed:12773384}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0007165	signal transduction
GO:0015031	protein transport
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2673998

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain

PFAM

PF00620
PF00018
PF14604
PF00787
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00326
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt