InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppap2b

Summary

InnateDB Protein

IDBP-169898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppap2b

Protein Name

phosphatidic acid phosphatase type 2B

Synonyms

1110003O22Rik; 2610002D05Rik; AV025606; D4Bwg0538e; D4Bwg1535e; Lpp3; Ppab2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065719

InnateDB Gene

IDBG-169896 (Ppap2b)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P) (By similarity). Essential to the formation of the chorioallantoic placenta and extraembryonic vasculature. Also mediates gastrulation and axis formation, probably by regulating the Wnt signaling pathway. {ECO:0000250, ECO:0000269PubMed:12925589}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Note=Ppap2b deficient embryos fail to form a chorioallantoic placenta and yolk sac vasculature. A subset of embryos also show a shortening of the anterior-posterior axis and frequent duplication of axial structures. Loss of Ppap2b results in a marked increase in beta-catenin-mediated T-cell factor (TCF) transcription. {ECO:0000269PubMed:12925589}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008195	phosphatidate phosphatase activity
GO:0042392	sphingosine-1-phosphate phosphatase activity
GO:0042577	lipid phosphatase activity

Biological Process

GO:0001568	blood vessel development
GO:0001702	gastrulation with mouth forming second
GO:0001933	negative regulation of protein phosphorylation
GO:0006644	phospholipid metabolic process
GO:0007155	cell adhesion
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030111	regulation of Wnt signaling pathway
GO:0034109	homotypic cell-cell adhesion
GO:0044328	canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration
GO:0044329	canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion
GO:0044330	canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060020	Bergmann glial cell differentiation
GO:0060070	canonical Wnt signaling pathway
GO:1902068	regulation of sphingolipid mediated signaling pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome