InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnrnpab

Summary

InnateDB Protein

IDBP-170115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpab

Protein Name

heterogeneous nuclear ribonucleoprotein A/B

Synonyms

3010025C11Rik; CBF-A; Cgbfa; Hnrpab;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074238

InnateDB Gene

IDBG-170113 (Hnrnpab)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes.

Subcellular Localization

Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001837	epithelial to mesenchymal transition
GO:0006351	transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated