Version 5.4
Mus musculus Protein: Tmem43
Summary
InnateDB Protein IDBP-170152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem43
Protein Name transmembrane protein 43
Synonyms 1200015A22Rik; LUMA;
Species Mus musculus
Ensembl Protein ENSMUSP00000032183
InnateDB Gene IDBG-170150 (Tmem43)
Protein Structure
UniProt Annotation
Function May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. {ECO:0000269PubMed:18230648}.
Subcellular Localization Endoplasmic reticulum. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1921372
InterPro IPR012430 Transmembrane protein 43 family
PFAM PF07787
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DBS1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 74122
UniGene Mm.396909
RefSeq NP_083042
MGI ID
MGI Symbol Tmem43
OMIM
CCDS CCDS20368
HPRD
IMGT
EMBL AK004778 AK151693 AK151766 AK152078 AK168559 BC024933
GenPept AAH24933 BAB23556 BAE30617 BAE30672 BAE30929 BAE40432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca