Version 5.4
Mus musculus Gene: Tmem43
Summary
InnateDB Gene IDBG-170150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem43
Gene Name transmembrane protein 43
Synonyms 1200015A22Rik; LUMA
Species Mus musculus
Ensembl Gene ENSMUSG00000030095
Encoded Proteins
IDBP-170152
transmembrane protein 43
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170876:
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:91473703-91488459
Strand Forward strand
Band D1
Transcripts
ENSMUST00000032183 ENSMUSP00000032183
ENSMUST00000153179
ENSMUST00000140246
ENSMUST00000144246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170876
View Gene Order
ENSBTAG00000007360
Not yet available
Cross-References
SwissProt Q9DBS1
TrEMBL
UniProt Splice Variant
Entrez Gene 74122
UniGene Mm.38801 Mm.396909
RefSeq NM_028766
OMIM
CCDS CCDS20368
HPRD
IMGT
MGI ID MGI:1921372
MGI Symbol Tmem43
EMBL AK004778 AK151693 AK151766 AK152078 AK168559 BC024933
GenPept AAH24933 BAB23556 BAE30617 BAE30672 BAE30929 BAE40432
RNA Seq Atlas 74122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca