Version 5.4
Mus musculus Protein: Scamp5
Summary
InnateDB Protein IDBP-170166.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scamp5
Protein Name secretory carrier membrane protein 5
Synonyms Sc5;
Species Mus musculus
Ensembl Protein ENSMUSP00000035898
InnateDB Gene IDBG-170164 (Scamp5)
Protein Structure
UniProt Annotation
Function Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11050114}; Multi-pass membrane protein {ECO:0000269PubMed:11050114}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269PubMed:11050114}; Multi- pass membrane protein {ECO:0000269PubMed:11050114}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Brain-specific. {ECO:0000269PubMed:11050114}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0015031 protein transport
GO:0034976 response to endoplasmic reticulum stress
GO:0045806 negative regulation of endocytosis
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0032588 trans-Golgi network membrane
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID MGI:1928948
InterPro IPR007273 SCAMP
PFAM PF04144
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKD3
PhosphoSite PhosphoSite-Q9JKD3
TrEMBL
UniProt Splice Variant
Entrez Gene 56807
UniGene Mm.407202
RefSeq NP_064666
MGI ID
MGI Symbol Scamp5
OMIM
CCDS CCDS40649
HPRD
IMGT
EMBL AF241833 BC018613
GenPept AAF64491 AAH18613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca