InnateDB Protein
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IDBP-170219.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Brd2
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Protein Name
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bromodomain containing 2
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Synonyms
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AW228947; D17H6S113E; Frg-1; Fsrg-1; Fsrg1; mKIAA4005; Nat; Ring3; Rnf3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000092990
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InnateDB Gene
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IDBG-170215 (Brd2)
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Protein Structure
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Function |
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis. {ECO:0000250, ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}. Note=Detected on chromatin and nucleosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the testis, followed by ovary, placenta, embryo and to a lower extent in somatic tissues. {ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99495
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InterPro |
IPR001487
Bromodomain
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PFAM |
PF00439
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q7JJ13
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TrEMBL |
U3KLT0
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UniProt Splice Variant |
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Entrez Gene |
14312
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UniGene |
Mm.413858
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RefSeq |
XP_006523722
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MGI ID |
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MGI Symbol |
Brd2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
CR974462
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GenPept |
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