InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pros1

Summary

InnateDB Protein

IDBP-170365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pros1

Protein Name

protein S (alpha)

Synonyms

AW214361;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023629

InnateDB Gene

IDBG-170363 (Pros1)

Protein Structure

UniProt Annotation

Function

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007596	blood coagulation
GO:0042730	fibrinolysis
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:1095733

InterPro

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00594
PF00008
PF00054
PF02210
PF07645

PRINTS

PR00001

PIRSF

SMART

SM00069
SM00181
SM00210
SM00282
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt