Version 5.4
Homo sapiens Protein: RIN3
Summary
InnateDB Protein IDBP-17046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIN3
Protein Name Ras and Rab interactor 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216487
InnateDB Gene IDBG-17044 (RIN3)
Protein Structure
UniProt Annotation
Function Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269PubMed:12972505, ECO:0000269PubMed:21586568}.
Subcellular Localization Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12972505}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding
Biological Process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005769 early endosome
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR000980 SH2 domain
IPR003123 Vacuolar sorting protein 9
IPR013995 Vacuolar sorting protein 9, subgroup
PFAM PF00788
PF00017
PF14633
PF02204
PRINTS PR00401
PIRSF
SMART SM00314
SM00252
SM00167
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TB24
PhosphoSite PhosphoSite-Q8TB24
TrEMBL Q5CZ74
UniProt Splice Variant
Entrez Gene 79890
UniGene
RefSeq NP_079108
HUGO HGNC:18751
OMIM 610223
CCDS CCDS32144
HPRD 11494
IMGT
EMBL AB060338 AB081753 AK021762 AK026092 AK074176 AK090451 AL136332 AL159141 BC025248 CR936654
GenPept AAH25248 BAB13888 BAB15357 BAB84316 BAB85002 BAC03432 BAC16513 CAI56792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca