InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smad1

Summary

InnateDB Protein

IDBP-170518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smad1

Protein Name

MAD homolog 1 (Drosophila)

Synonyms

AI528653; Madh1; Madr1; Mlp1; MusMLP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071035

InnateDB Gene

IDBG-170516 (Smad1)

Protein Structure

UniProt Annotation

Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). {ECO:0000250, ECO:0000269PubMed:15329343}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	118 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001710	mesodermal cell fate commitment
GO:0001822	kidney development
GO:0002051	osteoblast fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007276	gamete generation
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0010243	response to organonitrogen compound
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0030509	BMP signaling pathway
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0042592	homeostatic process
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051216	cartilage development
GO:0060038	cardiac muscle cell proliferation
GO:0060348	bone development
GO:0061036	positive regulation of cartilage development
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:109452

InterPro

IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
IPR019471 Interferon regulatory factor-3

PFAM

PF03166
PF03165
PF10401

PRINTS

PIRSF

SMART

SM00524
SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70340