Version 5.4
Mus musculus Protein: Smad1
Summary
InnateDB Protein IDBP-170520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad1
Protein Name MAD homolog 1 (Drosophila)
Synonyms AI528653; Madh1; Madr1; Mlp1; MusMLP;
Species Mus musculus
Ensembl Protein ENSMUSP00000064015
InnateDB Gene IDBG-170516 (Smad1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 118 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0001710 mesodermal cell fate commitment
GO:0002051 osteoblast fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007276 gamete generation
GO:0008285 negative regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030509 BMP signaling pathway
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0042592 homeostatic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051216 cartilage development
GO:0060038 cardiac muscle cell proliferation
GO:0060348 bone development
GO:0061036 positive regulation of cartilage development
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:109452
InterPro IPR003619 MAD homology 1, Dwarfin-type
IPR013019 MAD homology, MH1
PFAM PF03165
PRINTS
PIRSF
SMART SM00523
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8CC31
UniProt Splice Variant
Entrez Gene 17125
UniGene Mm.422314
RefSeq
MGI ID
MGI Symbol Smad1
OMIM
CCDS
HPRD
IMGT
EMBL AC101790 AC124201 AK034045
GenPept BAC28558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca