InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pou1f1

Summary

InnateDB Protein

IDBP-170698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pou1f1

Protein Name

POU domain, class 1, transcription factor 1

Synonyms

dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1; Pit1-rs1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004964

InnateDB Gene

IDBG-170694 (Pou1f1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0021983	pituitary gland development
GO:0021984	adenohypophysis development
GO:0030183	B cell differentiation
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0040018	positive regulation of multicellular organism growth
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051169	nuclear transport
GO:0060126	somatotropin secreting cell differentiation
GO:0060133	somatotropin secreting cell development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:97588

InterPro

IPR000327 POU-specific
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013847 POU domain

PFAM

PF00157
PF00046
PF13413

PRINTS

PR00028

PIRSF

SMART

SM00352
SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F8WGJ8

UniProt Splice Variant

Entrez Gene

18736

UniGene

Mm.477357

RefSeq

XP_006523018

MGI ID

MGI Symbol

Pou1f1

OMIM

CCDS

HPRD

IMGT

EMBL

AC118240 CT009578

GenPept