Version 5.4
Mus musculus Gene: Pou1f1
Summary
InnateDB Gene IDBG-170694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou1f1
Gene Name POU domain, class 1, transcription factor 1
Synonyms dw; dwarf; GHF-1; Hmp1; Pit-1; Pit1; Pit1-rs1
Species Mus musculus
Ensembl Gene ENSMUSG00000004842
Encoded Proteins
IDBP-170698
POU domain, class 1, transcription factor 1
IDBP-707154
IDBP-706453
IDBP-787714
POU domain, class 1, transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064835:
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:65520511-65535005
Strand Forward strand
Band C1.3
Transcripts
ENSMUST00000004964 ENSMUSP00000004964
ENSMUST00000176330 ENSMUSP00000135113
ENSMUST00000176038 ENSMUSP00000135574
ENSMUST00000175882
ENSMUST00000184525 ENSMUSP00000139087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001708 cell fate specification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0008340 determination of adult lifespan
GO:0021983 pituitary gland development
GO:0021984 adenohypophysis development
GO:0030183 B cell differentiation
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0040018 positive regulation of multicellular organism growth
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051169 nuclear transport
GO:0060126 somatotropin secreting cell differentiation
GO:0060133 somatotropin secreting cell development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064835
View Gene Order
ENSBTAG00000009128
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.355440 Mm.477357
RefSeq NM_008849 XM_006522955
OMIM
CCDS CCDS57033
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca