InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edil3

Summary

InnateDB Protein

IDBP-170707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edil3

Protein Name

EGF-like repeats and discoidin I-like domains 3

Synonyms

Del-1; Del1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080462

InnateDB Gene

IDBG-170705 (Edil3)

Protein Structure

UniProt Annotation

Function

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in angioblasts and early endothelial cells. By embryonic day 13.5, also expressed in a restricted group of non-endothelial cells including chondrocytes and retinal neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0010811	positive regulation of cell-substrate adhesion
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1329025

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR008979 Galactose-binding domain-like
IPR013111 EGF-like domain, extracellular

PFAM

PF00754
PF00008
PF07645
PF07974

PRINTS

PIRSF

SMART

SM00231
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35474